• Alvocidib,alsoknownasflavopiridolorHMR-1275,isacyclin-dependentkinase(CDK)inhibitor.
• Alvocidibisabroad-spectruminhibitorofCDKsandtargetstheirATPbindingsites.Itpromotescellcyclearrestandapoptosis,inducesdifferentiation,blockstranscriptionelongation,andinhibitsangiogenesis.Senderowicz,A.M."Small-moleculecyclin-dependentkinasemodulators."Oncogene22:6609-6620(2003).
• Administrationofflavopiridoltoolder(>70years)chroniclymphocyticleukemiapatientsisfeasIBLe,tolerable,andhascomparableefficacytothatinyoungerpatients(<70 years). Stephens, D.M., et al. "Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach." Haematologica 97: 423-427 (2012).
• Preclinicalstudieshaveshownthatalvocidibinducesapoptosisinbothnormalandmalignantcells,particularlythoseofhematopoieticorigin.Arguello,F.,etal."Flavopiridolinducesapoptosisofnormallymphoidcells,causesimmunosuppression,andhaspotentantitumoractivityinvivoagainsthumanleukemiaandlymphomaxenografts."Blood91:2482-2490(1998).
• Alvocidibpotentiatespaclitaxel-inducedapoptosisinthehumangastricandbreastcancercelllinesMKN-74andMCF-7.Motwani,M.,etal."Sequentialdependentenhancementofcaspaseactivationandapoptosisbyflavopiridolonpaclitaxel-treatedhumangastricandbreastcancercells."Clin.CancerRes.5:1876-1883(1999).
• Alvocidib(100-200nM)potentiatesphorbol12-myristate13-acetate(PMA,10nM)-inducedapoptosisinhumanmyeloidleukemiacellsU937andHL-60.Cartee,L.,etal."Synergisticinductionofapoptosisinhumanmyeloidleukemiacellsbyphorbol12-myristate13-acetateandflavopiridolproceedsviaactivationofboththeintrinsicandtumornecrosisfactor-mediatedextrinsiccelldeathpathways."Mol.Pharmacol.61:1313-1321(2002).
• Inearlyclinicaltrials,alvocidibdemonstratedlimitedactivityinpatientswithgastriccarcinomaandlungcancer.Schwartz,G.K.,etal."PhaseIIStudyoftheCyclin-DependentKinaseInhibitorFlavopiridolAdmiNISTeredtoPatientsWithAdvancedGastricCarcinoma."J.Clin.Oncol.19:1985-1992(2001).Shapiro,G.I.,etal."APhaseIITrialoftheCyclin-dependentKinaseInhibitorFlavopiridolinPatientswithPreviouslyUntreatedStageIVNon-SmallCellLungCancer."Clin.CancerRes.7:1590-1599(2001).
• Invitro,alvocidibinhibitedproliferationofhumanandmousesynovialfibroblasts.Invivo,treatmentwithalvocidibsuppressedsynovialhyperplasiaandjointdestructioninmicewithcollagen-inducedarthritis.Sekine,C.,etal."Successfultreatmentofanimalmodelsofrheumatoidarthritiswithsmall-moleculecyclin-dependentkinaseinhibitors."J.Immunol.180:1954-1961(2008).
• AlvocidibhaspotentantiviralactivityinvitroagainestHIV-1andHSV-1.Schang,L.M."Effectsofpharmacologicalcyclin-dependentkinaseinhibitorsonviraltranscriptionandreplication."Biochim.Biophys.Acta.1697:197-209(2004).
• RelatedCASnumbers:131740-09-5forthehydrochloridesalt.
• AnotherCASnumberpreviouslyassignedtoalvocidibfreebase,namely358739-39-6,hasbeendeletedbyCASandisnolongerinuse.
• Soldforlaboratoryormanufacturingpurposesonly;notforhuman,veterinary,food,orhouseholduse.
• ThisproductisofferedforR&Duseinaccordancewith(i)35USC271(e)+A13(1)intheU.S.;(ii)Section69.1ofJapanesePatentLawinJapan;(iii)Section11,No.2oftheGermanPatentActof1981inGermany;(iv)Section60,Paragraph5boftheU.K.PatentsActof1977intheU.K.;(v)Sections55.2(1)and55.2(6)andothercommonlawexemptionsofCanADIanpatentlaw;(vi)Section68BofthePatentsActof1953inNewZealandtogetherwiththeamendmentofsamebytheStatutesAmendmentBillof2002;(vii)suchrelatedlegislationand/orcaselawasmaybeorbecomeapplicableintheaforementionedcountries;and(viii)suchsimilarlawsandrulesasmayapplyinvariousothercountries.
• Notavailableinsomecountries;notavailabletosomeinstitutions;notavailableforsomeuses.

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